Endocrine Abstracts

Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized oncological treatment and substantially improved a prognosis for patients with advanced malignancy. ICIs inhibit the immunological pathways controlling T-cell activation or anergy. The most frequently used classes of ICIs are those that targeted and inhibit cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell death receptor 1 (PD-1) or its ligand PD-L1. The initiation of ICIs therapy is ofte...

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited kidney disease characterized by the development and growth of cysts causing a progressive kidney enlargement and the end-stage renal disease (ESRD). The incidence of brain aneurysms in patients with ADPKD is high thus screening is recommended. The association of pituitary incidentalomas and ADPKD is rarely described in the literature. All reported pituitary adenomas in patients with ADPKD were f...

Introduction: Thyrotoxic cardiomyopathy is a rare but potentially fatal form of dilated cardiomyopathy caused by hyperthyroidism not timely diagnosed or inadequately treated. The first-line treatment is a treatment of the underlying thyroid disease as the structural and functional cardiac alterations are potentially reversible after achieving a euthyroid state.Case presentation: A 41-year-old man was admitted to hospital due to the symptoms of heart fail...